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Adequacy of Fine Needle Aspiration Biopsies by Rapid On-Site Evaluation: An update

Published: 16th Mar 2021   |   Last Updated: 27th Nov 2024

Words: 1301    Pages: 6

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Fine Needle Aspiration Biopsies (FNAB) with Rapid On-Site Evaluation (ROSE) has become a crucial tool in medical diagnosis. It's appreciated for its convenience, quickness, and ability to provide dependable results. As it involves quickly testing cell samples taken with a fine needle on the spot, it helps doctors plan treatments and eases patients' anxiety over test results. Getting test results right away, either at the patient's bedside or in the clinic, greatly helps doctors diagnose and manage patients effectively. So, the mix of speed, accuracy, and efficiency makes ROSE a valuable advancement in medicine.

The Principle and Procedure of Rapid On-Site Evaluation (ROSE) for FNA Biopsies

The Rapid On-Site Evaluation (ROSE) for Fine Needle Aspiration (FNA) biopsies is a medical technique with an interesting history. Its development dates back to the latter part of the 20th century, particularly the 1970s and 1980s. The technique was created as a response to the need for a quicker, more efficient method of diagnosing diseases using tissue samples. By implementing ROSE, doctors and pathologists could instantly evaluate the sample's adequacy during the FNA biopsy procedure. This on-the-spot evaluation reduces the number of repeat tests, making patients' diagnosis journeys less cumbersome. The technique was a significant leap forward in providing immediate feedback about sample quality and suitability for full diagnostic testing.

Understanding the Principle of Rapid On-Site Evaluation (ROSE) for FNA Biopsies

FNA is a process of collecting cell material from deep body parts using a thin needle. The quality of the collected sample impacts the biopsy's accuracy. Use the ROSE technique. ROSE immediately evaluates the collected cell sample and guides the doctor if more samples are needed. In short, ROSE significantly increases the precision and effectiveness of FNA biopsies.

Step-by-Step Procedure of Rapid On-Site Evaluation (ROSE) for FNA Biopsies

The updated process goes like this: a pathologist or cytotechnologist does the FNA, taking several samples from various parts of the suspected lesion. Then, quickly smear the samples onto slides. After rapidly air-drying them or fixing them with alcohol, the smears are colored. The pathologist or cytotechnologist examines the sample under a microscope on-site to check the cell adequacy. If the sample is not enough, the clinician can do the FNA again to get more cells for examination. This quick analysis allows immediate feedback about the sample quality to the clinician and thus avoids the need to do the biopsy again.

Recent Developments in the ROSE Approach for FNA Biopsies

It used to be that we'd have to send these samples away to be checked, but now there's a better system known as Rapid On-Site Evaluation (ROSE), which can quickly assess the samples on-site. The ROSE technique can improve the biopsy process. It works by examining the biopsy samples right away, right there. The doctor can look at the cells and give a quick initial diagnosis. This method provides immediate feedback about the sample quality, something not possible with the old FNA method.

Use ROSE to cut down on time and potentially reduce health care costs. Before we had ROSE, FNA samples often weren't good enough, requiring repeated procedures. Using ROSE can substantially lower these inadequacy rates. This method is particularly helpful when diagnosing pancreatic and lung lesions. ROSE also lets doctors adjust their approach during the procedure itself, thanks to instant feedback. But we need to consider the cost and availability of experts needed for ROSE.

Assessing the Adequacy of FNA Biopsies Conducted by ROSE

Rapid On-Site Evaluation (ROSE) significantly improves this process, making it more reliable and reducing the chances of obtaining incomplete or non-diagnostic results. With ROSE, you can get real-time feedback and judge the sample on site, reducing the necessity of repeat procedures and aiding in getting a specific diagnosis. Having a sufficient sample for the FNA biopsy is important. It means there are enough relevant cells to confidently get a result. If you measure this adequacy using ROSE, you can improve the accuracy of your diagnosis because you can quickly check the quality of the sample and the site from where you took it.

In addition, ROSE lets you adjust how you handle the sample based on the initial results, making sure the most suited material is available for further tests. This wouldn't be possible without a real-time check. This method speeds up the diagnosis, saves resources, and lessens the patient's stress related to waiting for results or needing to do the procedure again. It's important to be careful when examining results because studying FNA biopsies with ROSE provides preliminary assessments, not final ones.

Case Studies and Statistical Evidence Supporting the Adequacy of FNA Biopsies by ROSE

They help to identify both harmless and harmful issues by testing cells from abnormal areas in the body. Research has shown how valuable this technique is. For example, a study in 2011 in the American Journal of Clinical Pathology found that using Rapid On-Site Evaluation (ROSE) along with FNA reduced unclear results from 26% to 7%. This means that ROSE helps doctors get better samples and make more reliable diagnoses. Investigate the application of ROSE in FNA more thoroughly. A 2016 study from the journal Cytopathology showed that ROSE helped with accurate diagnoses in 95% of cases examined. This tells us that the quick results from ROSE can make FNA tests more precise and effective. Also, using ROSE with FNA can reduce costs.

Challenges and Limitations of FNA Biopsies by ROSE

Rapid On-Site Evaluation (ROSE) has significantly improved the effectiveness of this practice, leading to more accurate diagnoses and reducing the risk of insufficient samples. Some issues still accompany FNA biopsies by ROSE and need to be acknowledged. One of the biggest issues with FNA biopsies by ROSE is the possibility of inadequacy. There are many instances where the tissue or cell samples taken may not be enough or diagnostic, causing potential errors in diagnosis, as well as possible false positives or negatives. This situation could happen due to several reasons, such as the lesion size, where it's located, the ability of the person doing the biopsy, or even the size of the needle used during the procedure. Another major difficulty is that ROSE largely depends on the quick assessment and judgment of the cytotechnologist or pathologist.

Possibilities for Future Improvements in FNA Biopsies through ROSE

The process has been improved by Rapid On-Site Evaluation (ROSE). But there's still a possibility for more growth in the future, especially about getting enough biopsy material. The amount and quality of the biopsy material—the cytological adequacy—are pivotal for diagnosing diseases accurately. At times, the sample taken might not be enough for a clear diagnosis, leading to more procedures or even wrong or missed diagnoses. This is what ROSE is working to improve. During the FNA biopsy, it helps doctors check the sample's adequacy in real time. Aim for the future improvement of digitizing ROSE, supported by the latest progress in imaging technology.

With digital ROSE, we can send high-quality images from the biopsy site to cytopathologists on the internet for instant checking. This will make the process quicker and easier. In remote areas, this change could be revolutionary, providing fast medical intervention when it's needed. One more possible growth area is involving artificial intelligence (AI) in the ROSE method. AI can learn from a variety of cell images to identify patterns and anomalies that could lead to fast and precise evaluations on-site.

The Concluding Thoughts

This way, you get better results faster. It also reduces the amount of non-useful samples, so you don't have to repeat the biopsy as much. Make sure to use this method. It not only makes patients more comfortable because they get fewer needle pricks, but it also improves the skills and confidence of pathologists. With the rise of personalized medicine and treatment, FNA with ROSE has proven to be very helpful. It's important that there is enough training, cooperation between departments, and resources for this method to work as well as it can.

References

1. Jiang D, Zang Y, Jiang D, Zhang X, Zhao C. Value of rapid on-site evaluation for ultrasound-guided thyroid fine needle aspiration. Journal of International Medical Research. 2018;47(2):626-634. doi:10.1177/0300060518807060

2. Padmanabhan V, Steinmetz HB, Rizzo EJ, et al. Improving Adequacy of Small Biopsy and Fine-Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients With Lung Cancer: A Quality Improvement Study at Dartmouth-Hitchcock Medical Center. Archives of Pathology & Laboratory Medicine. 2016;141(3):402-409. doi:10.5858/arpa.2016-0096-oa

3. Walia S, Aron M, Hu E, Chopra S. Utility of rapid on-site evaluation for needle core biopsies and fine-needle aspiration cytology done for diagnosis of mass lesions of the liver. Journal of the American Society of Cytopathology. 2019;8(2):69-77. doi:10.1016/j.jasc.2018.08.001

4. Michael CW, Kameyama K, Kitagawa W, Azar N. Rapid on-site evaluation (ROSE) for fine needle aspiration of thyroid: benefits, challenges and innovative solutions. Gland Surgery. 2020;9(5):1708-1715. doi:10.21037/gs-2019-catp-23

5. Medina Chamorro FM, Calle JA, Stein JE, Merchancano L, Mendoza Briñez AM, Pulido Wilches AA. Experience of the Implementation of Rapid On-Site Evaluation in Ultrasound-Guided Fine-Needle Aspiration Biopsy of Thyroid Nodules. Current Problems in Diagnostic Radiology. 2018;47(4):220-224. doi:10.1067/j.cpradiol.2017.06.009

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